Crustaceans are a group of arthropods that includes familiar animals like crabs, shrimp, and lobsters, as well as thousands of other species with extremely varied ways of life, including sessile, shell-incased barnacles, swimming centipede-like remipedes, giant deep-sea isopods, and many others. For centuries scientists have debated how these various animals are related to one another, and this still remains a mystery today. By using large genomic and transcriptomic datasets, I hope to build a better picture of the crustacean tree of life.
Copepods are a group of small aquatic crustaceans containing 11,000 species that are likely the most abundant animals in the ocean. Most copepods are about the size and shape of a grain of rice, but their small size belies their essential role in ecosystems. They are ubiquitous in aquatic environments from mountain streams to all depths of the ocean and are even abundant in canopy mosses and wet soil. Most ocean animals are directly or indirectly dependent on copepods as a food source. In addition, about half of all copepods (6,000 species) are parasites of other animals. I am particularly interested in parasitic copepods. I use microscopy to identify copepods, describe new species, and document their morphology, and next-generation sequencing (NGS) to understand how copepods are related to each other and how they have diversified.
|Image credit: Andrei Savitsky / CC BY-SA|
Tapeworm Taxonomy and Systematics
Tapeworms are parasites that live in the intestines of vertebrates. They lack all elements of a digestive tract, instead they rely on their host for nutrients, which tapeworms absorb through the surfaces of their body. I have described 5 species of tapeworms from sharks and documented a novel attachment mechanism in a genus of shark tapeworms. While most tapeworms attach with their head, a specialized attachment organ called a scolex, species of Calliobothrium use, to a much greater extent, spikey structures along the length of their body to attach to the villi on the gut of their hosts.
I apply computational biology methods to answer biological questions. Often, these questions are related to the topics above, but I have also collaborated in a variety of other areas including human gene expression in cancer, mouse models of human disease, fish microbiome characterization, and hookworm developmental gene expression. My computational biology work has involved phylogenetics, phylogenomics, ortholog identification, microbiome analysis, transcriptome assembly, genome assembly, and differential gene expression analyses.